Cousin Eddie (Golden Globe® winner Quaid, Elvis, Category 6: Day Of Destruction) and his family have been freeloading off of his niece Audrey Griswold. Things don't get any better when Eddie loses his job and is attacked by a monkey in the nuclear-testing laboratory. To avoid a lawsuit, the company offers the family an all-expenses paid trip to the tropics. Eddie's crazy, horny Uncle Nick (Golden Globe® and Emmy® Award winner Asner, Out Of The Woods) shows up in time to go on the trip. Once there, the family soaks up the sun and takes in the gorgeous sights of the island with their sexy tour guide. While on a fishing trip, Eddie catches a giant shark that drags the boat out to sea, abandoning them on a deserted island. The laughs come fast as Eddie and his family devise various survival tactics and try to make it off the island.